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Integrin beta 4 (4I13) Rabbit Monoclonal Antibody  Cite:0    分享

货号: IM35159
复制产品信息
  • 种属:H,M
  • 用途:WB,IHC-P,IHC-F
规格:
50µl 100µl
单位:
单价:¥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM35159
  • 纯度
    Affinity-chromatography
  • 别名
    CD104; gp150; Integrin beta 4 subunit; ITG B4; ITGB 4; Itgb4;
  • 产品名称
    Integrin beta 4 (4I13) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    ITGB4
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IHC-F
  • 反应种属
    Human,Mouse
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    3691
  • Human Swissprot No.
    P16144
  • 稀释度
    WB 1:1000-1:2000,IHC-P/IHC-F 1:100-1:200
  • 参考分子量
    210kDa
  • 预测分子量
    202kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Integrin beta 4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach
  • 细胞定位
    Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome Note=Colocalizes with DST at the leading edge of migrating keratinocytes
  • 功能
    Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
储存与保存

1.保存:-20℃

2.有效期:1年

注意事项

1.我司生产的生化试剂如无特殊标注,基本为非无菌包装,若用于细胞实验,请提前做好预处理。需低温保存的产品,一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。 

 

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