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JAK1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM54044
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  • 种属：H，M，R
  • 用途：WB，ELISA，IP，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1200.00
产品介绍
储存与保存
注意事项
产品介绍
  • 货号
    IM54044
  • 别名
    JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1
  • 产品名称
    JAK1 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    JAK1
  • 蛋白名称
    Tyrosine-protein kinase JAK1
  • Clonality
    Polyclonal
  • 推荐应用
    IF-P,IF-F,IF-ICC,WB,IP,IHC-P,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    3716
  • Human Swissprot No.
    P23458
  • Mouse Swissprot No.
    P52332
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human JAK1. AA range:988-1037
  • 特异性
    JAK1 Polyclonal Antibody detects endogenous levels of JAK1 protein.
  • 稀释度
    IF-P/IF-F/IF-ICC 1:50-200, WB 1:200-1:1000, IHC-P 1:100-1:300, ELISA 1:10000.Not yet tested in other applications.
  • 预测分子量
    132kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
  • 组织表达
    Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
  • 细胞定位
    Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
  • 信号通路
    Jak_STAT;Pathways in cancer;Pancreatic cancer;
  • 功能
    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃

2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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