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MYO7A (11M17) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM35920
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  • 种属：H，M，R
  • 用途：WB，FCM，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM35920
  • 纯度
    Affinity-chromatography
  • 别名
    DFNA11; DFNB2; Myo7a; MYU7A; NSRD2; Ush1b;
  • 产品名称
    MYO7A (11M17) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    MYO7A
  • 蛋白名称
    USH1B
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC,FCM
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    4647
  • Human Swissprot No.
    Q13402
  • 稀释度
    WB 1:1000-1:2000,IF-ICC 1:50-1:200,FCM 1:20-1:100
  • 参考分子量
    254kDa
  • 预测分子量
    254kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    MYO7A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain
  • 细胞定位
    Cytoplasm {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97479}. Cell junction, synapse. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (PubMed:8842737). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (PubMed:19643958, PubMed:27331610). Detected at the tip of cochlear hair cell stereocilia (PubMed:21709241). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (PubMed:21709241).
  • 功能
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由普通住宅区。 

3.为了您的多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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