热搜词： 生化试剂 血清抗 细胞 pvdf膜 抗体

咨询热线

13564444959

产品中心

当前位置：首页 > 产品中心 > 抗体蛋白 > 一抗
产品中心
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
MESP2 Rabbit pAb  Cite:0    分享

货号： IM47918
复制产品信息
  • 种属：H，M，R，Dg
  • 用途：IF，IHC-P，IHC-F
规格:
50μl 100μl
单位:
支
单价:￥1350.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM47918
  • 产品名称
    MESP2 Rabbit pAb
  • 别名
    SCDO2; bHLHc6; MESP2_HUMAN; MESP2; Class C basic helix-loop-helix protein 6 (bHLHc6);
  • 抗体来源
    Rabbit
  • 克隆类型
    Polyclonal
  • 交叉反应
    Rat (predicted: Human,Mouse,Dog)
  • 产品应用
    IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
  • 理论分子量
    42 kDa
  • 细胞定位
    细胞核
  • 性状
    Liquid
  • 浓度
    1mg/ml
  • 免疫原
    KLH conjugated synthetic peptide derived from human MESP2: 311-397/397
  • 亚型
    IgG
  • 纯化方法
    affinity purified by Protein A
  • 缓冲液
    0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
  • 产品介绍
    This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
  • Function
    Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
  • Subcellular Location
    Nucleus.
  • Post-translational modifications
    Degraded by the proteasome.
  • DISEASE
    Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2) [MIM:608681]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • Similarity
    Contains 1 bHLH (basic helix-loop-helix) domain.
  • SWISS
    Q0VG99
  • Gene ID
    145873
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。

产品推荐
<