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Ub Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM30003
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  • 种属：H，M，R
  • 用途：WB，ELISA，IP，IHC-P，IF-P，IF-F，IF-ICC
规格:
20ug 50ug 100ug
单位:
支
单价:￥550.00
详细信息
储存与保存
注意事项
详细信息
  • 别名
    UBB; Polyubiquitin-B; UBC; Polyubiquitin-C; RPS27A; UBA80; UBCEP1; Ubiquitin-40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80; UBA52; UBCEP2; Ubiquitin-60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal pr
  • 产品名称
    Ub Rabbit Polyclonal Antibody
  • 类别
    抗原抗体
  • 基因名称
    UBA52/RPS27A/UBB/UBC
  • 蛋白名称
    Ubiquitin
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IP,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    7311
  • Human Swissprot No.
    P0CG47/P0CG48/P62979/P62987
  • Mouse Gene ID
    22187/22190/78294/22186
  • Rat Gene ID
    192255/50522/100912032/64156
  • Rat Swissprot No.
    P0CG51/Q63429/P62982/P62986
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human Ubiquitin. AA range:40-89
  • 特异性
    Ub Polyclonal Antibody detects endogenous levels of Ub protein.
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:20000, IF-P/IF-F/IF-ICC 1:50-200
  • 参考分子量
    18kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • 组织表达
    Brain,Epithelium,Fetal brain cortex,Liver,Lung,Lung adenocarcinoma,Lung cancer,Lymphocyte,P
  • 细胞定位
    [Ubiquitin]: Cytoplasm . Nucleus . Mitochondrion outer membrane ; Peripheral membrane protein .
  • 功能
    function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.,miscellaneous:This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.,miscellaneous:Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).,PTM:Several types of polymeric chains can be formed, depending on the lysine used for the assembly.,similarity:Belongs to the ribosomal protein S27Ae family.,similarity:Belongs to the ubiquitin family.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃

2.有效期：1年

注意事项

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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