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Tbx21 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM35986
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  • 种属：H，M
  • 用途：WB，IF，IHC-P，IHC-F
规格:
50µl 100µl
单位:
支
单价:￥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM35986
  • 产品名称
    Tbx21 Rabbit Polyclonal Antibody
  • 抗体来源
    Rabbit
  • 交叉反应
    Human,Mouse (predicted: Rat,Pig,Cow,Dog,Horse)
  • 产品应用
    WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
  • 理论分子量
    59 kDa
  • 细胞定位
    细胞核
  • 性状
    Liquid
  • 浓度
    1mg/ml
  • 免疫原
    KLH conjugated synthetic peptide derived from human Tbx21: 201-300/535
  • 亚型
    IgG
  • 克隆类型
    Polyclonal
  • 缓冲液
    0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
  • 产品介绍
    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008].
  • Function
    Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
  • Subcellular Location
    Nucleus.
  • Tissue Specificity
    T-cell specific.
  • DISEASE
    Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
  • Similarity
    Contains 1 T-box DNA-binding domain.
  • SWISS
    Q9UL17
  • Gene ID
    30009
  • 纯化方法
    affinity purified by Protein A
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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