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FGF2 (19T17) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM35078
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  • 种属：H，M
  • 用途：WB，FCM，IP，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM35078
  • 纯度
    Affinity-chromatography
  • 别名
    Basic fibroblast growth factor; BFGF; FGF2; FGF2 basic; FGF2; FGFB; Fibroblast growth factor 2 (basic); HBGF2;
  • 产品名称
    FGF2 (19T17) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    FGF2
  • 蛋白名称
    FGFB
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC,FCM,IP
  • 反应种属
    Human,Mouse
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    2247
  • Human Swissprot No.
    P09038
  • 免疫原
    Recombinant protein of human FGF2
  • 稀释度
    WB 1:1000, IF-ICC 1:200-1:500, FCM 1:200-1:500, IP 1:20-1:50
  • 参考分子量
    19kDa
  • 预测分子量
    31kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 组织表达
    Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
  • 细胞定位
    Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063)
  • 功能
    Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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