热搜词： 生化试剂 血清抗 细胞 pvdf膜 抗体

咨询热线

13564444959

产品中心

当前位置：首页 > 产品中心 > 抗体蛋白 > 一抗
产品中心
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
Hsp90 beta (14O5) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM34363
复制产品信息
  • 种属：H，M，R
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Hsp90 beta (14O5) Rabbit Monoclonal Antibody
  • 别名
    HS90B; HSP 84; HSP90-beta; HSP90AB1; HSPC2; HSPCB; Heat shock protein HSP 90-beta
  • 类别
    抗体产品
  • 基因名称
    HSP90AB1
  • 蛋白名称
    HSP90B, HSPC2, HSPCB
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-ICC,FCM,IP
  • 稀释度
    WB 1:1000-1:5000, IHC-P/IF-P 1:200-1:1000, IF-ICC 1:100-1:200, FCM 1:200-1:500, IP 1:100
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    3326
  • Human Swissprot No.
    P08238
  • 免疫原
    Recombinant protein of human Hsp90 beta
  • 参考分子量
    90kDa
  • 预测分子量
    85,83kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 细胞定位
    Cytoplasm. Melanosome Nucleus. Secreted. Cell membrane. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6AZV1}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762).
  • 功能
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1- mediated inhibition of TGF-beta signaling via inhibition of STUB1- mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059).
  • 纯化
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。

产品推荐
<