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COLQ Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM57396
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  • 种属：H，M，R
  • 用途：WB，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM57396
  • 别名
    Acetylcholinesterase collagenic tail peptide (AChE Q subunit;Acetylcholinesterase-associated collagen)
  • 产品名称
    COLQ Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    COLQ
  • 蛋白名称
    COLQ
  • Clonality
    Polyclonal
  • 推荐应用
    IHC-P,IF-P,IF-F,IF-ICC,WB
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    8292
  • Human Swissprot No.
    Q9Y215
  • 免疫原
    Synthesized peptide derived from human COLQ
  • 特异性
    This antibody detects endogenous levels of human COLQ
  • 稀释度
    IHC-P 1:50-200, WB 1:500-2000, IF-P/IF-F/IF-ICC 1:50-200
  • 预测分子量
    50kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
  • 组织表达
    Found at the end plate of skeletal muscle.
  • 细胞定位
    Cell junction, synapse.
  • 功能
    disease:Defects in COLQ are the cause of congenital myasthenic syndrome Engel type (CMSE) [MIM:603034]; also known as end-plate acetylcholinesterase deficiency or congenital myasthenic syndrome type IC (CMS-IC). CMSE is a rare autosomal recessive congenital myastehnic syndrome characterized by onset during childhood, generalized weakness, abnormal fatigability on exertion, refrectoriness to acetylcholinesterase drugs, decremental electromyographic response and morphological abnormalities of the neuromuscular junctions.,domain:The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.,function:Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.,PTM:The triple-helical tail is stabilized by disulfide bonds at each end.,similarity:Belongs to the COLQ family.,similarity:Contains 2 collagen-like domains.,subunit:Homotrimer. Component of the asymmetric form of AChE, a disulfide-bonded oligomer composed of the collagenic subunits (Q) and a variable number of asymmetric catalytic subunits (T). The N-terminal of a collagenic subunit (Q) associates with the C-terminal of a catalytic subunit (T).,tissue specificity:Found at the end plate of skeletal muscle.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

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