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Synaptotagmin XI Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM55796
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM55796
  • 别名
    SYT11; KIAA0080; Synaptotagmin-11; Synaptotagmin XI; SytXI
  • 产品名称
    Synaptotagmin XI Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    SYT11
  • 蛋白名称
    Synaptotagmin-11
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    23208
  • Human Swissprot No.
    Q9BT88
  • Mouse Gene ID
    229521
  • Mouse Swissprot No.
    Q9R0N3
  • Rat Swissprot No.
    O08835
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human SYT11. AA range:181-230
  • 特异性
    Synaptotagmin XI Polyclonal Antibody detects endogenous levels of Synaptotagmin XI protein.
  • 稀释度
    WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications.
  • 预测分子量
    48kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    synaptotagmin 11(SYT11) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010],
  • 组织表达
    Amygdala,Bone marrow,Brain,Lymph,
  • 细胞定位
    Cytoplasmic vesicle membrane ; Single-pass membrane protein . Perikaryon . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Recycling endosome membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, phagosome . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Recycling endosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass membrane protein . Perikaryon . Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity). Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients (PubMed:12925569).
  • 功能
    cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,PTM:Ubiquitinated and targeted to the proteasome complex for degradation.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.,subunit:Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

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