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Cerebellin 1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM52760
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Cerebellin 1 Rabbit Polyclonal Antibody
  • 别名
    CBLN1; Cerebellin-1; Precerebellin
  • 类别
    抗体产品
  • 基因名称
    CBLN1
  • 蛋白名称
    Cerebellin-1
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications.
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    869
  • Human Swissprot No.
    P23435
  • Mouse Gene ID
    12404
  • Mouse Swissprot No.
    Q9R171
  • Rat Gene ID
    498922
  • Rat Swissprot No.
    P63182
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human CBLN1. AA range:131-180
  • 特异性
    Cerebellin 1 Polyclonal Antibody detects endogenous levels of Cerebellin 1 protein.
  • 预测分子量
    25kDa
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008],
  • 组织表达
    In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • 细胞定位
    Secreted . Cell junction, synapse, postsynaptic cell membrane .
  • 功能
    developmental stage:Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.,function:Cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.,function:Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.,PTM:The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.,similarity:Contains 1 C1q domain.,subcellular location:Might be bound to, or associated with, a membrane.,subunit:Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. Probably forms a heteomeric complex with CBLN3. May interact with CBLN2 and CBLN4.,tissue specificity:In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

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