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c-Myc (phospho Thr58) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM50841
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  • 种属：H，M，R
  • 用途：WB，ELISA，IP，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    c-Myc (phospho Thr58) Rabbit Polyclonal Antibody
  • 别名
    MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
  • 类别
    抗体产品
  • 基因名称
    MYC
  • 蛋白名称
    Myc proto-oncogene protein
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-1:300, Immunoprecipitation 2-5 ug/mg lysate, ELISA 1:10000, IF-P/IF-F/IF-ICC 1:50-200
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    4609
  • Human Swissprot No.
    P01106
  • Mouse Gene ID
    17869
  • Mouse Swissprot No.
    P01108
  • Rat Gene ID
    24577
  • Rat Swissprot No.
    P09416
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr58. AA range:25-74
  • 特异性
    Phospho-c-Myc (T58) Polyclonal Antibody detects endogenous levels of c-Myc protein only when phosphorylated at T58.
  • 预测分子量
    50,(also ~60kDa in some samples)
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],
  • 组织表达
    Cervix,Epithelium,Leukemia,Placenta,Promyelocytic l
  • 细胞定位
    Nucleus, nucleoplasm . Nucleus, nucleolus .
  • 信号通路
    Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; WNT;WNT-T CELL;β-Catenin; ErbB/HER; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation
  • 功能
    disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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