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SFRP1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM49769
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    SFRP1 Rabbit Polyclonal Antibody
  • 别名
    FRP;FRP1;SARP2
  • 类别
    抗体产品
  • 基因名称
    SFRP1
  • 蛋白名称
    Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    6422
  • Human Swissprot No.
    Q8N474
  • Mouse Swissprot No.
    Q8C4U3
  • Rat Swissprot No.
    Q9R168
  • 免疫原
    Synthesized peptide derived from part region of human protein
  • 特异性
    SFRP1 Polyclonal Antibody detects endogenous levels of protein.
  • 预测分子量
    34kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009],
  • 组织表达
    Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
  • 细胞定位
    Secreted. Cell membrane or extracellular matrix-associated. Released by heparin-binding.
  • 信号通路
    WNT;WNT-T CELL
  • 功能
    domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.,induction:Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions.,mass spectrometry:Isoform N-glycosylated on Asn-173 PubMed:11741940,miscellaneous:May have therapeutic use in cardiac surgery.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,subcellular location:Cell membrane or extracellular matrix-associated. Released by heparin-binding.,subunit:Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8.,tissue specificity:Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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