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ZO1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM49208
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  • 种属：H，M，Pg
  • 用途：WB，ELISA，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM49208
  • 别名
    ZO1
  • 产品名称
    ZO1 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    TJP1
  • 蛋白名称
    Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Mouse,Pig
  • 同源性
    Rabbit（94.06%）
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    7082
  • Human Swissprot No.
    Q07157
  • Mouse Swissprot No.
    P39447
  • 免疫原
    Synthesized peptide derived from part region of human protein.AA1600-1700
  • 特异性
    ZO1 Polyclonal Antibody detects endogenous levels of protein.
  • 稀释度
    WB 1:500-2000, IF-P/IF-F/IF-ICC 1:100-300, ELISA 1:5000-20000
  • 预测分子量
    192kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014],
  • 组织表达
    The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
  • 细胞定位
    Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, tight junction . Cell junction . Cell junction, gap junction. Cell projection, podosome . Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225).
  • 信号通路
    Adherens_Junction;Adherens_Junction;Gap junction;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;
  • 功能
    domain:The second PDZ domain mediates interaction with GJA12.,function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.,PTM:Phosphorylated.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 3 PDZ (DHR) domains.,subcellular location:Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact.,subunit:Interacts with HSPA4 and KIRREL1 (By similarity). Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with occludin, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1.,tissue specificity:The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

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