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AMPKβ2 (Mix-mA) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM47101
复制产品信息
  • 种属：H，M，R
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    AMPKβ2 (Mix-mA) Mouse Monoclonal Antibody
  • 别名
    5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
  • 类别
    抗体产品
  • 基因名称
    PRKAB2
  • 蛋白名称
    AMPKβ2
  • Clonality
    Monoclonal
  • 推荐应用
    IHC-P,WB
  • 稀释度
    IHC-P 1:50-200, WB 1:1000-2000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5565
  • Human Swissprot No.
    O43741
  • Mouse Gene ID
    108097
  • Mouse Swissprot No.
    Q6PAM0
  • Rat Gene ID
    64562
  • Rat Swissprot No.
    Q9QZH4
  • 免疫原
    Synthesized peptide derived from human AMPKβ2
  • 特异性
    This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat
  • 预测分子量
    30kDa
  • 宿主
    Mouse
  • 背景介绍
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
  • 组织表达
    Liver,Pancreas
  • 细胞定位
    nucleoplasm,cytosol,nucleotide-activated protein kinase complex
  • 功能
    function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits.
  • 纯化
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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