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AMPKβ1 (Mix-mA) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM47102
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  • 种属：H，M，R
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    AMPKβ1 (Mix-mA) Mouse Monoclonal Antibody
  • 别名
    5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb);AMPK
  • 类别
    抗体产品
  • 基因名称
    PRKAB1
  • 蛋白名称
    AMPKβ1
  • Clonality
    Monoclonal
  • 推荐应用
    IHC-P,WB
  • 稀释度
    IHC-P 1:50-200, WB 1:1000-2000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5564
  • Human Swissprot No.
    Q9Y478
  • Mouse Gene ID
    19079
  • Mouse Swissprot No.
    Q9R078
  • Rat Gene ID
    83803
  • Rat Swissprot No.
    P80386
  • 免疫原
    Synthesized peptide derived from human AMPKβ1
  • 特异性
    This antibody detects endogenous levels of AMPKβ1 at Human, Mouse,Rat
  • 预测分子量
    38kDa
  • 宿主
    Mouse
  • 背景介绍
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided
  • 组织表达
    Brain,Lung,Muscle,Platelet
  • 细胞定位
    nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex
  • 功能
    function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit.,PTM:Phosphorylated.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.
  • 纯化
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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