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FGF-2 Protein, Mouse, Recombinant  Cite:0    分享

货号： IM36016
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规格:
5μg 10μg 20μg 50μg 100μg 200μg 500μg 1mg
单位:
支
单价:￥450.00
基本信息
产品简介
运输与保存
注意事项
基本信息
  • 产品名称
    FGF-2 Protein, Mouse, Recombinant
  • 别名
    Heparin-Binding Growth Factor 2, HBGF-2, Fibroblast Growth Factor 2, Fgf-2, Fgf2, bFGF, Basic Fibroblast Growth Factor
  • 种属
    Mouse
  • 表达系统
    E. coli
  • 标签
    Tag Free
  • 蛋白编号
    P15655
  • 氨基酸序列
    Met1-Ser154
  • 蛋白构建
    Met1-Ser154
  • 蛋白纯度
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
  • 分子量
    16 KDa (reducing condition)
  • 缓冲液
    Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 400 mM NaCl, 0.02% Tween 80, 4.0% Sucrose, 4.0% Manntiol, pH 7.0.
  • 复溶方法
    Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
  • 内毒素
    < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
  • 生物活性
    Measured in a cell proliferation assay using BALB/c 3T3 cells. The ED50 for this effect is 0.3-1.8 ng/ml. (QC verified)
  • 研究背景
    FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity. Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis is reminiscent of a variety of pathological conditions.
产品简介

FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity. Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis is reminiscent of a variety of pathological conditions.

运输与保存
  • Shipping
    In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice
  • Stability & Storage
    It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can bestably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstitutedprotein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freezethaw cycles and store products in aliquots
注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。

 

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