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GAPDH (12R9) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM12059
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  • 种属：H，M，R，Mk，Dg，Rab
  • 用途：WB，ELISA
规格:
20μl 50μl 100μl 1ml
单位:
支
单价:￥200.00
产品详情
产品图片
注意事项
产品详情
  • 产品货号
    IM12059
  • 别名
    GAPDH;GAPD;CDABP0047;OK/SW-cl.12;Glyceraldehyde-3-phosphate dehydrogenase;GAPDH;Peptidyl-cysteine S-nitrosylase GAPDH
  • 产品名称
    GAPDH (12R9) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 蛋白名称
    Glyceraldehyde-3-phosphate dehydrogenase
  • 推荐应用
    WB,ELISA
  • 反应种属
    Human,Mouse,Rat,Rabbit,Dog,Monkey
  • 存储缓冲液
    PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • Human Gene ID
    2597
  • 免疫原
    Synthesized peptide derived from human protein. AA range:200-300
  • 特异性
    endogenous
  • 稀释度
    WB 1:500-2000, ELISA 1:20000
  • 参考分子量
    37kDa
  • 预测分子量
    37kDa
  • 运输及保存条件
    -15°C to -25°C/1 year(Do not lower than -25°C)
  • 宿主
    Monoclonal Rabbit IgG1, Kappa
  • 背景介绍
    glyceraldehyde-3-phosphate dehydrogenase(GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferri
  • 细胞定位
    Cytoplasm, cytosol . Nucleus . Cytoplasm, perinuclear region . Membrane . Cytoplasm, cytoskeleton . Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions (PubMed:12829261).
  • 表达
    Astrocytoma,Brain,Cajal-Retzius cell,Colon adenocarcinoma,Epitheliu
  • 功能
    catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.,function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.,online information:Glyceraldehyde 3-phosphate dehydrogenase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis.,sequence caution:Differs quite extensively.
  • 纯化
    Protein A
产品图片

14a2fe0c59f737657262fe2dde3c02e5_B8016.jpg

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with GAPDH Rabbit Monoclonal Antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1:PT0004R Lane 2: mouse testis Predicted band size: 37kDa Observed band size: 37kDa

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1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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