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alpha Synuclein (Phospho Y125) (12J1) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37167
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37167
  • 纯度
    Affinity-chromatography
  • 别名
    Alpha synuclein; alphaSYN; NACP; PARK1; PARK4; Parkinson disease familial 1; SNCA; SYN; Synuclein alpha 140.
  • 产品名称
    alpha Synuclein (Phospho Y125) (12J1) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    SNCA
  • 蛋白名称
    NACP, PARK1
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    6622
  • Human Swissprot No.
    P37840
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Tyr125 of human Alpha-synuclein
  • 稀释度
    WB 1:1000-1:5000
  • 参考分子量
    16kDa
  • 预测分子量
    14kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-alpha Synuclein (Y125) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
  • 细胞定位
    Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted Note=Membrane-bound in dopaminergic neurons.
  • 功能
    Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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