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Caveolin-1 (Phospho Y14) (3O19) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37151
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37151
  • 纯度
    Affinity-chromatography
  • 别名
    BSCL3; CAV; CAV1; Caveolin1; CGL3; LCCNS; PPH3; VIP21
  • 产品名称
    Caveolin-1 (Phospho Y14) (3O19) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CAV1
  • 蛋白名称
    CAV
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    857
  • Human Swissprot No.
    Q03135
  • 稀释度
    WB 1:1000-1:2000
  • 参考分子量
    23kDa
  • 预测分子量
    20kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-Caveolin-1 (Y14) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
  • 细胞定位
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724} Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • 功能
    May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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