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SYVN1 / HRD1 (16L10) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37140
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  • 种属：H，M，R
  • 用途：WB，FCM，IP，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37140
  • 纯度
    Affinity-chromatography
  • 别名
    DER3; E3 ubiquitin-protein ligase synoviolin; HRD1; Synovial apoptosis inhibitor 1; Synoviolin 1; Synoviolin 1 isoform b; SYNOVIOLIN; SYVN1.
  • 产品名称
    SYVN1 / HRD1 (16L10) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    SYVN1
  • 蛋白名称
    HRD1, KIAA1810
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC,IP,FCM
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    84447
  • Human Swissprot No.
    Q86TM6
  • 稀释度
    WB 1:1000-1:2000,IF-ICC 1:50-1:200,IP 1:20-1:50,FCM 1:20-1:100
  • 参考分子量
    65kDa
  • 预测分子量
    68kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    SYVN1 / HRD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level)
  • 细胞定位
    Endoplasmic reticulum membrane; Multi-pass membrane protein
  • 功能
    E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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