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CTNND1 (Phospho Y228) (13I7) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37135
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  • 种属：H，M，R
  • 用途：WB，IHC-P，IF-P
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37135
  • 纯度
    Affinity-chromatography
  • 别名
    Cadherin associated Src substrate; CAS; Catenin (cadherin associated protein) delta 1; Catenin delta 1; Catenin delta; CTNND; CTNND1; delta 1 Catenin; p120; P120 CAS; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN.
  • 产品名称
    delta 1 Catenin (Phospho Tyr228) (13I7) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CTNND1
  • 蛋白名称
    KIAA0384
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    1500
  • Human Swissprot No.
    O60716
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Tyr228 of human delta 1 Catenin
  • 稀释度
    WB 1:2000-1:20000, IHC-P/IF-P 1:50
  • 参考分子量
    95-100kDa
  • 预测分子量
    108kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-CTNND1 (Y228) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs
  • 细胞定位
    Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell- cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187) {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063} [Isoform 2A]: Nucleus.
  • 功能
    Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476).
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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