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JAK2 (Phospho Y1007 + Y1008) (17F11) Rabbit Monoclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM34963
复制产品信息
  • 种属：H，M，R
  • 用途：WB，FCM，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    JAK2 (Phospho Y1007 + Y1008) (17F11) Rabbit Monoclonal Antibody
  • 别名
    EC 2.7.10.2; JAK-2; JAK2; Janus kinase 2; kinase Jak2
  • 类别
    抗体产品
  • 基因名称
    JAK2
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-ICC,FCM
  • 稀释度
    WB 1:1000-1:5000, IHC-P/IF-P 1:1000-1:10000, IF-ICC 1:200-1:1000, FCM 1:20
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    3717
  • Human Swissprot No.
    O60674
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Tyr1007/Tyr1008 of human JAK2
  • 参考分子量
    125kDa
  • 预测分子量
    131kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 组织表达
    Ubiquitously expressed throughout most tissues.
  • 细胞定位
    Endomembrane system; Peripheral membrane protein. Cytoplasm. Nucleus
  • 功能
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).
  • 纯化
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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