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ErbB2 (HER2) (4J7) Rabbit Monoclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM34276
复制产品信息
  • 种属：H，R
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    ErbB2 (HER2) (4J7) Rabbit Monoclonal Antibody
  • 别名
    C-erbB-2; ErbB2; HER2, MLN 19; NEU; NEU proto-oncogene; NGL; Receptor protein-tyrosine kinase erbB-2;
  • 类别
    抗体产品
  • 基因名称
    ERBB2
  • 蛋白名称
    HER2, MLN19, NEU, NGL
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-ICC,FCM,IP,IF-P
  • 稀释度
    WB 1:1000, IHC-P/IF-P 1:500-1:2000, IF-ICC 1:100-1:200, FCM 1:50-1:100, IP 1:20-1:50
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    2064
  • Human Swissprot No.
    P04626
  • 免疫原
    A synthetic peptide of human ErbB 2
  • 参考分子量
    185kDa
  • 预测分子量
    138kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 组织表达
    Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
  • 细胞定位
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). [Isoform 3]: Cytoplasm. Nucleus.
  • 功能
    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
  • 纯化
    Affinity-chromatography
储存与保存

1. 保存：-20℃，Avoid freeze/thaw cycles

2. 有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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