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抗体蛋白
二抗生物素标记 过氧化物酶(HRP)标记 胶体金试剂 FITC荧光标记 RBITC荧光标记 二抗免疫血清 其它荧光标记二抗 藻红蛋白(PE)荧光标记 胶体金(Gold)标记 SAlexa Fluor荧光系列 碱性磷酸酶(AP)标记 别藻蓝蛋白(APC)荧光标记 其它标记 PE标记二抗 DyLight标记二抗 AU标记二抗 Biotin标记二抗 AMCA标记二抗 Texas Red标记二抗 TRITC标记二抗 HRP标记二抗 未标记二抗 Cy标记二抗 AbBox Fluor标记二抗内参抗体 小分子抗体抗体标记试剂盒细菌抗体蛋白病毒包装试剂杂交瘤融合筛选WB、IHC、ELISA相关试剂细胞培养试剂病原微生物抗原抗体假病毒抗体校准品其他抗原抗体标记的标签抗体病理级IHC抗体重组蛋白
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斑马鱼产品
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
抗体类满2送1 产品简介
储存与保存
注意事项
产品简介-
产品名称CD40 ligand Rabbit Polyclonal Antibody
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别名CD40 ligand (CD40-L;T-cell antigen Gp39;TNF-related activation protein;TRAP;Tumor necrosis factor ligand superfamily member 5;CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form];CD40L;TNFSF5;TRAP
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类别抗体产品
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基因名称CD40LG
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蛋白名称CD40 ligand
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ClonalityPolyclonal
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推荐应用WB,ELISA
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稀释度WB 1:1000-2000, ELISA 1:5000-20000
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反应种属Human,Rat,Mouse
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浓度1 mg/ml
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存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
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Human Gene ID959
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Human Swissprot No.P29965
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Mouse Gene ID21947
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Mouse Swissprot No.P27548
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Rat Gene ID84349
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Rat Swissprot No.Q9Z2V2
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免疫原Synthesized peptide derived from human CD40 ligand
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特异性This antibody detects endogenous levels of Human CD40 ligand
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参考分子量29kDa
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宿主Rabbit
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同种型Rabbit,IgG
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背景介绍disease:Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.,function:Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.,function:Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.,online information:CD40L defect database,PTM:N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.,PTM:Not O-glycosylated.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed on activated CD4+ T-lymphocytes.,
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组织表达Specifically expressed on activated CD4+ T-lymphocytes.
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细胞定位Cell membrane ; Single-pass type II membrane protein . Cell surface .; [CD40 ligand, soluble form]: Secreted . Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. .
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功能cell activation, regulation of cytokine production, positive regulation of cytokine production, somatic diversification of immune receptors, somatic recombination of immunoglobulin genes during immune response, somatic diversification of immunoglobulins during immune response, adaptive immune response, immune effector process, immunoglobulin production, immunoglobulin production during immune response, production of molecular mediator of immune response, leukocyte mediated immunity, lymphocyte mediated immunity, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, immune system development,leukocyte differentiation, somatic diversification of immune receptors via germline recombination within a single locus,regulation of immunoglobulin production, regulation of immune effector process, regulation of production of molecular mediator of immune response, DNA metabolic process, DNA recombination, anti-apoptosis, defense response,inflammatory response, immune response, cell adhesion, leukocyte adhesion, blood coagulation, hemostasis, protein localization, cell proliferation, protein secretion, response to wounding, regulation of cell death, protein transport,immunoglobulin mediated immune response, cell-cell adhesion, somatic cell DNA recombination, somatic diversification of immunoglobulins, somatic recombination of immunoglobulin gene segments, B cell mediated immunity, biological adhesion, hemopoiesis, lymphocyte differentiation, platelet activation, B cell differentiation, regulation of interleukin-12 production, positive regulation of interleukin-12 production, regulation of protein localization, secretion by cell,mononuclear cell proliferation, wound healing, B cell proliferation, B cell activation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,establishment of protein localization, isotype switching, leukocyte activation, lymphocyte activation, lymphocyte proliferation, secretion, immunoglobulin secretion, hemopoietic or lymphoid organ development, regulation of protein secretion, coagulation, regulation of body fluid levels, regulation of immunoglobulin secretion, regulation of secretion,regulation of protein transport, positive regulation of multicellular organismal process, regulation of cellular localization, negative regulation of cell death, regulation of establishment of protein localization, leukocyte proliferation,
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纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存1.保存：-20℃，Avoid freeze/thaw cycles
2.有效期：1年
注意事项1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。
备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。
