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IL-6 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM56635
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1400.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM56635
  • 别名
    IL6; IFNB2; Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
  • 产品名称
    IL-6 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    IL6
  • 蛋白名称
    Interleukin-6
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Rat,Mouse
  • 同源性
    Macaca fascicularis（96.70%）
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    3569
  • Human Swissprot No.
    P05231
  • Mouse Swissprot No.
    P08505
  • 免疫原
    The antiserum was produced against synthesized peptide derived from the Internal region of human IL6. AA range:131-180
  • 特异性
    IL-6 Polyclonal Antibody detects endogenous levels of IL-6 protein.
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-300, ELISA 1:20000, IF-P/IF-F/IF-ICC 1:100-300, Not yet tested in other applications.
  • 预测分子量
    23kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
  • 组织表达
    Produced by skeletal muscle.
  • 细胞定位
    Secreted .
  • 信号通路
    Cytokine-cytokine receptor interaction;Toll_Like;NOD-like receptor;Cytosolic DNA-sensing pathway;Jak_STAT;Hematopoietic cell lineage;Intestinal immune network for IgA production;Prion diseases;Pathways in cancer;Graft-versus-host disease;Hypertrophic cardiomyopathy (HCM);
  • 功能
    disease:At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.,disease:Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.,online information:Interleukin-6 entry,online information:The Singapore human mutation and polymorphism database,polymorphism:Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,PTM:N- and O-glycosylated.,similarity:Belongs to the IL-6 superfamily.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

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