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IL-4 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM53986
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  • 种属：H，M
  • 用途：WB，ELISA，Flow Cyt
规格:
50μl 100μl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM53986
  • 别名
    IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
  • 产品名称
    IL-4 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    IL4
  • 蛋白名称
    Interleukin-4
  • Clonality
    Polyclonal
  • 推荐应用
    WB,Flow Cyt,ELISA
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    3565
  • Human Swissprot No.
    P05112
  • Mouse Swissprot No.
    P07750
  • 免疫原
    Synthesized peptide derived from the C-terminal region of human IL-4.
  • 特异性
    IL-4 Polyclonal Antibody detects endogenous levels of IL-4 protein.
  • 稀释度
    WB 1:500-2000, Flow Cyt 1:50-200, ELISA 1:5000-20000
  • 预测分子量
    18kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
  • 组织表达
    Blood,PCR rescued clones,
  • 细胞定位
    Secreted.
  • 信号通路
    Cytokine-cytokine receptor interaction;Jak_STAT;Hematopoietic cell lineage;T_Cell_Receptor;Fc epsilon RI;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Allograft rejection;
  • 功能
    disease:Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.,similarity:Belongs to the IL-4/IL-13 family.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。

3.为了您的安全和健康，请穿实验服并戴一次性手套操作。

4.实验结果受多种因素影响，相关处理仅限于产品本身，不涉及其他赔偿。

 

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