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TBK1/NAK (Phospho Ser172) Rabbit Polyclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM59650
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  • 种属：H，M
  • 用途：ELISA
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    TBK1/NAK (Phospho Ser172) Rabbit Polyclonal Antibody
  • 别名
    Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1);NAK
  • 类别
    抗体产品
  • 基因名称
    TBK1
  • 蛋白名称
    TBK1/NAK (Ser172)
  • Clonality
    Polyclonal
  • 推荐应用
    ELISA
  • 稀释度
    ELISA 1:5000-20000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    29110
  • Human Swissprot No.
    Q9UHD2
  • Mouse Gene ID
    56480
  • Mouse Swissprot No.
    Q9WUN2
  • 免疫原
    Synthesized phosho peptide around human TBK1 and NAK (Ser172)
  • 特异性
    This antibody detects endogenous levels of Human Mouse TBK1/NAK (phospho-Ser172)
  • 预测分子量
    80kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 组织表达
    Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.
  • 细胞定位
    Cytoplasm . Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. .
  • 信号通路
    Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
  • 功能
    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein.,tissue specificity:Ubiquitous with higher expression in testis.,
  • 纯化
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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