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EphA2/5 (phospho Tyr594) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM51275
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  • 种属：H，M
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    EphA2/5 (phospho Tyr594) Rabbit Polyclonal Antibody
  • 别名
    EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA5; BSK; EHK1; HEK7; TYRO4; Ephrin type-A receptor 5; Brain-specific kinase; EPH homology kinase 1; EHK-1; EPH-like kinase 7; EK7; hEK7;EPHA5
  • 类别
    抗体产品
  • 基因名称
    EPHA2
  • 蛋白名称
    Ephrin type-A receptor 2/5
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    1969/2044
  • Human Swissprot No.
    P29317/P54756
  • Mouse Gene ID
    13836/13839
  • 免疫原
    Synthesized phospho-peptide around the phosphorylation site of human EphA2/5 (phospho Tyr594)
  • 特异性
    Phospho-EphA2/5 (Y594) Polyclonal Antibody detects endogenous levels of EphA2/5 protein only when phosphorylated at Y594.
  • 稀释度
    WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications.
  • 预测分子量
    110kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010],
  • 组织表达
    Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.
  • 细胞定位
    Cell membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein . Cell junction, focal adhesion . Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). .
  • 信号通路
    Axon guidance;
  • 功能
    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with SLA (By similarity). Interacts with INPPL1/SHIP2.,tissue specificity:Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1. 保存：-20℃，Avoid freeze/thaw cycles

2. 有效期：1年

注意事项

1. 我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

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