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Stat5 (phospho Tyr694/699) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM51025
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1400.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM51025
  • 别名
    STAT5A; STAT5; Signal transducer and activator of transcription 5A; STAT5B; Signal transducer and activator of transcription 5B;STAT5B
  • 产品名称
    Stat5 (phospho Tyr694/699) Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    STAT5A
  • 蛋白名称
    Signal transducer and activator of transcription 5A/B
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 储存缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    6776/6777
  • Human Swissprot No.
    P42229/P51692
  • Mouse Gene ID
    20850/20851
  • Rat Gene ID
    24918/25126
  • Rat Swissprot No.
    Q62771/P52632
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human STAT5A around the phosphorylation site of Tyr694. AA range:666-715
  • 特异性
    Phospho-Stat5 (Y694/699) Polyclonal Antibody detects endogenous levels of Stat5 protein only when phosphorylated at Y694/699.
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:20000, IF-P/IF-F/IF-ICC 1:50-200
  • 预测分子量
    91kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
  • 组织表达
    Brain,Cervix,Epithelium,Lung,Placenta,Synovial memb
  • 细胞定位
    Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
  • 信号通路
    ErbB_HER;Jak_STAT;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
  • 功能
    function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,PTM:Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

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4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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