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VEGFR1 (PTR1311) Mouse Monoclonal Antibody  Cite:0    分享
抗体类满2送1  

货号： IM65391
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  • 种属：H
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    VEGFR1 (PTR1311) Mouse Monoclonal Antibody
  • 别名
    Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor);FLT;FRT;VEGFR1
  • 类别
    抗体产品
  • 基因名称
    FLT1
  • 蛋白名称
    Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-2000, IF-P/IF-F/IF-ICC 1:100-500, ELISA 1:1000-5000
  • 反应种属
    Human
  • 浓度
    1 mg/ml
  • 制备方法
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    2321
  • Human Swissprot No.
    P17948
  • Mouse Gene ID
    14254
  • Mouse Swissprot No.
    P35969
  • Rat Gene ID
    54251
  • Rat Swissprot No.
    P53767
  • 特异性
    This antibody detects endogenous levels of VEGFR1 at Human; Maybe react with mouse, rat
  • 参考分子量
    150kDa
  • 组织表达
    Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
  • 细胞定位
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .
  • 功能
    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 . ; [Isoform 1]: Phosphorylates PLCG. ; [Isoform 2]: May function as decoy receptor for VEGFA. ; [Isoform 3]: May function as decoy receptor for VEGFA. ; [Isoform 4]: May function as decoy receptor for VEGFA. ; [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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