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AMPK γ1 (5H5) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM47413
复制产品信息
  • 种属：H，M，R
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    AMPK γ1 (5H5) Mouse Monoclonal Antibody
  • 别名
    5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)
  • 类别
    抗体产品
  • 基因名称
    PRKAG1
  • 蛋白名称
    AMPK γ1
  • Clonality
    Monoclonal
  • 推荐应用
    IHC-P,WB
  • 稀释度
    IHC-P 1:50-200, WB 1:1000-2000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5571
  • Human Swissprot No.
    P54619
  • Mouse Gene ID
    19082
  • Mouse Swissprot No.
    O54950
  • Rat Gene ID
    25520
  • Rat Swissprot No.
    P80385
  • 免疫原
    Synthesized peptide derived from human AMPK γ1
  • 特异性
    This antibody detects endogenous levels of AMPK γ1 at Human, Mouse,Rat
  • 预测分子量
    38kDa
  • 宿主
    Mouse
  • 背景介绍
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
  • 组织表达
    Fetal liver,Muscle,Testis
  • 细胞定位
    nucleoplasm,cytosol,membrane,nucleotide-activated protein kinase complex,extracellular exosome,
  • 功能
    function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase gamma subunit family.,similarity:Contains 4 CBS domains.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.,
  • 纯化
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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