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SET7 (SET9) Rabbit Polyclonal Antibody (Center)  Cite:0    分享

货号： IM30459
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  • 种属：H，M
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1100.00
产品简介
注意事项
产品简介
  • 产品货号
    IM30459
  • 别名
    Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7, KIAA1717, KMT7, SET7, SET9
  • 产品名称
    SET7 (SET9) Rabbit Polyclonal Antibody (Center)
  • 类别
    抗体产品
  • Clonality
    Polyclonal
  • 推荐应用
    WB
  • 反应种属
    Human, Mouse
  • Human Gene ID
    NP_085151.1
  • Human Swissprot No.
    Q8WTS6
  • 特异性
    This SET7 (SET9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-189 amino acids from the Central region of human SET7 (SET9).
  • 稀释度
    WB 1:1000
  • 预测分子量
    41kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 背景介绍
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
  • 组织表达
    Widely expressed. Expressed in pancreatic islets.
  • 细胞定位
    Nucleus. Chromosome.
  • 纯化
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
注意事项

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。

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