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Caveolin-1 (16G7) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM34126
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  • 种属：H，M
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
20µl 50µl 100µl
单位:
支
单价:￥600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM34126
  • 别名
    BSCL3; CGL3; caveolin 1, caveolae protein, 22kDa; Caveolin-1; VIP21; CAV; CAV1.
  • 产品名称
    Caveolin-1 (16G7) Rabbit Monoclonal Antibody
  • 类别
    抗原抗体
  • 基因名称
    CAV1
  • 蛋白名称
    CAV
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-ICC,FCM,IP,IF-P
  • 反应种属
    Human,Mouse
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • 免疫原
    Recombinant protein of human Caveolin-1
  • 稀释度
    WB 1:2000, IHC-P/IF-P 1:20-1:500, IF-ICC 1:50, FCM 1:20, IP 1:20
  • 参考分子量
    20kDa
  • 预测分子量
    20kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Caveolin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain
  • 细胞定位
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724} Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae
  • 功能
    May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
储存与保存
1.保存：-20℃
2.有效期：1年
注意事项
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。

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